URINARY STEROIDS ISOLATED AFTER ADMINISTRATION OF DEHYDROISOANDROSTERONE TO HUMAN SUBJECTS

Studies on phenolic steroids in human subjects.

Duration of Suppression of Adrenal Steroids after Glucocorticoid Administration

Hydrocortisone has long been the treatment of choice for congenital adrenal hyperplasia (CAH). However, treatment with this medication remains problematic. Patients with 21-hydroxylase deficiency CAH have significant diurnal variation in the secretion of 17-hydroxyprogesterone (17OHP). When considering treatment strategies, this variation must be considered along with the pharmacokinetic and ph...

Urinary Steroids of Cats

Adrenal steroid secretion by cats has been studied by Bush (1951, 1953) and reviewed by Dorfman (1959). The cat adrenal secretes both cortisol and corticosterone. Arteta & Borrell (1958) and Borrell (1958) have reported studies of urinary excretion of 17-hydroxy corticosteroids (PorterSilber chromogens). Cats appear to excrete in urine very low concentrations of 17-hydroxy corticosteroids, all ...

Intranasal administration of gentamicin in human subjects.

The effectiveness of gentamicin administered by the intranasal route in healthy human volunteers was studied. Thirty minutes after gentamicin in a solution of 1% sodium glycocholate was administered at 2 mg/kg of body weight, gentamicin concentrations of 2.48 +/- 0.42 mg/ml were present in the sera. Serum concentrations decreased to 0.94 +/- 0.13 mg/ml at 180 min. No serious side effects were o...

Urinary oxalate, citrate, and gamma glutamyl transferase alterations after administration of Cynodon dactylon extract in cats

BACKGROUND: Urinary oxalate and citrate are the keyfactors in caox urolithiasis of cats and Gamma GlutamylTransferase is a good test for assessment of kidney damage.Favorable effects of Cynodon dactylon on calcium oxalate stoneformation have recently been proved in rats. OBJECTIVES: Thepresent study was designed to investigate the alteration ofurinary oxalate, citrate, and GGT after administrat...